More results...

Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Filter by Categories
Abdominal Radiology, Original Research
Abdominal Radiology, Pictorial Essay
Anthropology and Dental Radiology, Original Research
Breast Imaging, Case Report
Breast Imaging, Original Research
Breast Imaging, Pictorial Essay
Breast Imaging, Review Article
Cardiopulmonary Imaging, Case Report
Cardiopulmonary Imaging, Case Series
Cardiopulmonary Imaging, Education
Cardiopulmonary Imaging, Original Research
Cardiopulmonary Imaging, Pictorial Essay
Cardiopulmonary Imaging, Review Article
Case Report
Case Report, Breast Imaging
Case Report, Cardiopulmonary Imaging
Case Report, Diagnostic Radiology
Case Report, Gastrointestinal Imaging
Case Report, Genitourinary and Gynecologic Imaging
Case Report, Neuroradiology/Head and Neck Imaging
Case Report, Vascular and Interventional Radiology
Case Series
Case Series, Abdominal Radiology
Case Series, Diagnostic Radiology
Case Series, Musculoskeletal Imaging
Case Series, Vascular and Interventional Radiology
DENTAL ARTICLE
Dental Radiology, Case Report
Dental Radiology, Case Series
Dental Radiology, Original Research
Diagnostic Radiology, Case Report
Diagnostic Radiology, Case Series
Diagnostic Radiology, Original Research
Diagnostic Radiology, Pictorial Essay
Diagnostic Radiology, Review Article
Editorial
Education
Education, Diagnostic Radiology
Education, Imaging science
Education, Original Research
Emergency, Original Research
Erratum
Gastrointestinal Imaging, Case Report
Gastrointestinal Imaging, Case Series
Gastrointestinal Imaging, Original Research
Gastrointestinal Imaging, Pictorial Essay
General and Emergency Radiology, Original Research
General and Emergency Radiology, Review Article
Genitourinary and Gynecologic Imaging, Case Report
Genitourinary and Gynecologic Imaging, Original Research
Imaging Science, Original Research
Interventional Radiology, Original Research
Letter to Editor
Musculoskeletal Imaging, Case Report
Musculoskeletal Imaging, Original Article
Musculoskeletal Imaging, Original Research
Musculoskeletal Imaging, Pictorial Essay
Musculoskeletal Imaging, Review Article
Neuroradiology , Review Article
Neuroradiology Head and Neck Imaging, Pictorial Essay
Neuroradiology, Case Report
Neuroradiology, Pictorial Essay
Neuroradiology/Head and Neck Imaging, Case Report
Neuroradiology/Head and Neck Imaging, Case Series
Neuroradiology/Head and Neck Imaging, Original Research
Neuroradiology/Head and Neck Imaging, Review Article
Neuroradiology/Spine Imaging, Original Research
Notice of Retraction
Nuclear Medicine, Case Report
Nuclear Medicine, Original Research
Nuclear Medicine, Pictorial Essay
Original Article
Original Article, Neuroradiology
Original Research
Original Research Article
Original Research, Cardiopulmonary Imaging
Original Research, Dental Radiology
Original Research, Descriptive Study
Original Research, Diagnostic Radiology
Original Research, Gastrointestinal Imaging
Original Research, Genitourinary and Gynecologic Imaging
Original Research, Musculoskeletal Imaging
Original Research, Neuroradiology/Head and Neck Imaging
Original Research, Nuclear Medicine
Original Research, Vascular and Interventional Radiology
Pediatric Imaging, Case Report
Pediatric Imaging, Pictorial Essay
PICTORIAL ESSAY
Pictorial essay, Musculoskeletal Imaging
Pictorial essay, Neuroradiology/Head and Neck Imaging
PICTORIAL REVIEW
Radiologic-Pathologic Correlation
RADIOLOGICAL-PATHOLOGICAL CORRELATION
Radiology Business, Original Research
Research Article
Review Article
Review Article, Diagnostic Radiology
Review Article, Gastrointestinal imaging
Review Article, Musculoskeletal
Review Article, Musculoskeletal Imaging
Review Article, Vascular and Interventional Radiology
Technical Innovation
Technical Innovation, Cardiopulmonary Imaging
Technical Innovation, Gastrointestinal Imaging
Ultrasound, Case Report
Ultrasound, Original Research
Ultrasound, Review Article
Vascular and International Radiology, Case Report
Vascular and Interventional Radiology, Case Report
Vascular and Interventional Radiology, Case Series
Vascular and Interventional Radiology, Original Research
Vascular and Interventional Radiology, Pictorial Essay
Vascular and Interventional Radiology, Review Article
Vascular and Interventional Radiology, Short Communication
Vascular and Interventional, Original Research

More results...

Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Filter by Categories
Abdominal Radiology, Original Research
Abdominal Radiology, Pictorial Essay
Anthropology and Dental Radiology, Original Research
Breast Imaging, Case Report
Breast Imaging, Original Research
Breast Imaging, Pictorial Essay
Breast Imaging, Review Article
Cardiopulmonary Imaging, Case Report
Cardiopulmonary Imaging, Case Series
Cardiopulmonary Imaging, Education
Cardiopulmonary Imaging, Original Research
Cardiopulmonary Imaging, Pictorial Essay
Cardiopulmonary Imaging, Review Article
Case Report
Case Report, Breast Imaging
Case Report, Cardiopulmonary Imaging
Case Report, Diagnostic Radiology
Case Report, Gastrointestinal Imaging
Case Report, Genitourinary and Gynecologic Imaging
Case Report, Neuroradiology/Head and Neck Imaging
Case Report, Vascular and Interventional Radiology
Case Series
Case Series, Abdominal Radiology
Case Series, Diagnostic Radiology
Case Series, Musculoskeletal Imaging
Case Series, Vascular and Interventional Radiology
DENTAL ARTICLE
Dental Radiology, Case Report
Dental Radiology, Case Series
Dental Radiology, Original Research
Diagnostic Radiology, Case Report
Diagnostic Radiology, Case Series
Diagnostic Radiology, Original Research
Diagnostic Radiology, Pictorial Essay
Diagnostic Radiology, Review Article
Editorial
Education
Education, Diagnostic Radiology
Education, Imaging science
Education, Original Research
Emergency, Original Research
Erratum
Gastrointestinal Imaging, Case Report
Gastrointestinal Imaging, Case Series
Gastrointestinal Imaging, Original Research
Gastrointestinal Imaging, Pictorial Essay
General and Emergency Radiology, Original Research
General and Emergency Radiology, Review Article
Genitourinary and Gynecologic Imaging, Case Report
Genitourinary and Gynecologic Imaging, Original Research
Imaging Science, Original Research
Interventional Radiology, Original Research
Letter to Editor
Musculoskeletal Imaging, Case Report
Musculoskeletal Imaging, Original Article
Musculoskeletal Imaging, Original Research
Musculoskeletal Imaging, Pictorial Essay
Musculoskeletal Imaging, Review Article
Neuroradiology , Review Article
Neuroradiology Head and Neck Imaging, Pictorial Essay
Neuroradiology, Case Report
Neuroradiology, Pictorial Essay
Neuroradiology/Head and Neck Imaging, Case Report
Neuroradiology/Head and Neck Imaging, Case Series
Neuroradiology/Head and Neck Imaging, Original Research
Neuroradiology/Head and Neck Imaging, Review Article
Neuroradiology/Spine Imaging, Original Research
Notice of Retraction
Nuclear Medicine, Case Report
Nuclear Medicine, Original Research
Nuclear Medicine, Pictorial Essay
Original Article
Original Article, Neuroradiology
Original Research
Original Research Article
Original Research, Cardiopulmonary Imaging
Original Research, Dental Radiology
Original Research, Descriptive Study
Original Research, Diagnostic Radiology
Original Research, Gastrointestinal Imaging
Original Research, Genitourinary and Gynecologic Imaging
Original Research, Musculoskeletal Imaging
Original Research, Neuroradiology/Head and Neck Imaging
Original Research, Nuclear Medicine
Original Research, Vascular and Interventional Radiology
Pediatric Imaging, Case Report
Pediatric Imaging, Pictorial Essay
PICTORIAL ESSAY
Pictorial essay, Musculoskeletal Imaging
Pictorial essay, Neuroradiology/Head and Neck Imaging
PICTORIAL REVIEW
Radiologic-Pathologic Correlation
RADIOLOGICAL-PATHOLOGICAL CORRELATION
Radiology Business, Original Research
Research Article
Review Article
Review Article, Diagnostic Radiology
Review Article, Gastrointestinal imaging
Review Article, Musculoskeletal
Review Article, Musculoskeletal Imaging
Review Article, Vascular and Interventional Radiology
Technical Innovation
Technical Innovation, Cardiopulmonary Imaging
Technical Innovation, Gastrointestinal Imaging
Ultrasound, Case Report
Ultrasound, Original Research
Ultrasound, Review Article
Vascular and International Radiology, Case Report
Vascular and Interventional Radiology, Case Report
Vascular and Interventional Radiology, Case Series
Vascular and Interventional Radiology, Original Research
Vascular and Interventional Radiology, Pictorial Essay
Vascular and Interventional Radiology, Review Article
Vascular and Interventional Radiology, Short Communication
Vascular and Interventional, Original Research

More results...

Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Filter by Categories
Abdominal Radiology, Original Research
Abdominal Radiology, Pictorial Essay
Anthropology and Dental Radiology, Original Research
Breast Imaging, Case Report
Breast Imaging, Original Research
Breast Imaging, Pictorial Essay
Breast Imaging, Review Article
Cardiopulmonary Imaging, Case Report
Cardiopulmonary Imaging, Case Series
Cardiopulmonary Imaging, Education
Cardiopulmonary Imaging, Original Research
Cardiopulmonary Imaging, Pictorial Essay
Cardiopulmonary Imaging, Review Article
Case Report
Case Report, Breast Imaging
Case Report, Cardiopulmonary Imaging
Case Report, Diagnostic Radiology
Case Report, Gastrointestinal Imaging
Case Report, Genitourinary and Gynecologic Imaging
Case Report, Neuroradiology/Head and Neck Imaging
Case Report, Vascular and Interventional Radiology
Case Series
Case Series, Abdominal Radiology
Case Series, Diagnostic Radiology
Case Series, Musculoskeletal Imaging
Case Series, Vascular and Interventional Radiology
DENTAL ARTICLE
Dental Radiology, Case Report
Dental Radiology, Case Series
Dental Radiology, Original Research
Diagnostic Radiology, Case Report
Diagnostic Radiology, Case Series
Diagnostic Radiology, Original Research
Diagnostic Radiology, Pictorial Essay
Diagnostic Radiology, Review Article
Editorial
Education
Education, Diagnostic Radiology
Education, Imaging science
Education, Original Research
Emergency, Original Research
Erratum
Gastrointestinal Imaging, Case Report
Gastrointestinal Imaging, Case Series
Gastrointestinal Imaging, Original Research
Gastrointestinal Imaging, Pictorial Essay
General and Emergency Radiology, Original Research
General and Emergency Radiology, Review Article
Genitourinary and Gynecologic Imaging, Case Report
Genitourinary and Gynecologic Imaging, Original Research
Imaging Science, Original Research
Interventional Radiology, Original Research
Letter to Editor
Musculoskeletal Imaging, Case Report
Musculoskeletal Imaging, Original Article
Musculoskeletal Imaging, Original Research
Musculoskeletal Imaging, Pictorial Essay
Musculoskeletal Imaging, Review Article
Neuroradiology , Review Article
Neuroradiology Head and Neck Imaging, Pictorial Essay
Neuroradiology, Case Report
Neuroradiology, Pictorial Essay
Neuroradiology/Head and Neck Imaging, Case Report
Neuroradiology/Head and Neck Imaging, Case Series
Neuroradiology/Head and Neck Imaging, Original Research
Neuroradiology/Head and Neck Imaging, Review Article
Neuroradiology/Spine Imaging, Original Research
Notice of Retraction
Nuclear Medicine, Case Report
Nuclear Medicine, Original Research
Nuclear Medicine, Pictorial Essay
Original Article
Original Article, Neuroradiology
Original Research
Original Research Article
Original Research, Cardiopulmonary Imaging
Original Research, Dental Radiology
Original Research, Descriptive Study
Original Research, Diagnostic Radiology
Original Research, Gastrointestinal Imaging
Original Research, Genitourinary and Gynecologic Imaging
Original Research, Musculoskeletal Imaging
Original Research, Neuroradiology/Head and Neck Imaging
Original Research, Nuclear Medicine
Original Research, Vascular and Interventional Radiology
Pediatric Imaging, Case Report
Pediatric Imaging, Pictorial Essay
PICTORIAL ESSAY
Pictorial essay, Musculoskeletal Imaging
Pictorial essay, Neuroradiology/Head and Neck Imaging
PICTORIAL REVIEW
Radiologic-Pathologic Correlation
RADIOLOGICAL-PATHOLOGICAL CORRELATION
Radiology Business, Original Research
Research Article
Review Article
Review Article, Diagnostic Radiology
Review Article, Gastrointestinal imaging
Review Article, Musculoskeletal
Review Article, Musculoskeletal Imaging
Review Article, Vascular and Interventional Radiology
Technical Innovation
Technical Innovation, Cardiopulmonary Imaging
Technical Innovation, Gastrointestinal Imaging
Ultrasound, Case Report
Ultrasound, Original Research
Ultrasound, Review Article
Vascular and International Radiology, Case Report
Vascular and Interventional Radiology, Case Report
Vascular and Interventional Radiology, Case Series
Vascular and Interventional Radiology, Original Research
Vascular and Interventional Radiology, Pictorial Essay
Vascular and Interventional Radiology, Review Article
Vascular and Interventional Radiology, Short Communication
Vascular and Interventional, Original Research
View/Download PDF

Translate this page into:

Case Series
Vascular and Interventional Radiology
2024
:14;
42
doi:
10.25259/JCIS_108_2024

Transarterial embolization of intralobar pulmonary sequestration in adult patients: A case series

Department of Medicine, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, United States
Department of Thoracic Surgery, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, United States
Department of Imaging Sciences, University of Rochester Medical Center, Rochester, United States
Department of Vascular Interventional Radiology, Great Lakes Medical Imaging, Buffalo, New York, United States.

*Corresponding author: Andrea Benson, Department of Medicine, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, United States. abenson@buffalo.edu

Licence
This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

How to cite this article: Benson A, Perry Y, Cantos A, Butani D, Chengazi H. Transarterial embolization of intralobar pulmonary sequestration in adult patients: A case series. J Clin Imaging Sci. 2024;14:42. doi: 10.25259/JCIS_108_2024

Abstract

Pulmonary sequestration is a malformation of lung tissue such that a zone of pulmonary parenchyma exists in isolation from the bronchopulmonary tree. This condition is typically treated with surgical resection, but an increasing number of sequestrations are being treated with arterial embolization. We report interventions that were performed at two institutions on patients 53–70 years old. One patient presented with chronic cough and the two other patients presented with hemoptysis. Two of the cases were managed solely by endovascular embolization of the arteries supplying the pulmonary sequestration. In one patient, embolization was performed to debulk the sequestration, followed by surgical resection. These cases suggest transcatheter embolization may be an effective treatment in adult patients with symptomatic pulmonary sequestrations.

Keywords

Pulmonary sequestration
Embolization
Intralobar pulmonary sequestration

INTRODUCTION

Pulmonary sequestration is a rare congenital lung malformation characterized by nonfunctioning lung tissue without communication with the tracheobronchial tree and instead receives blood supply from non-pulmonary systemic arteries. This anomaly makes up 0.15–6.4% of all congenital pulmonary malformations and are classified as extralobular and intralobar.[1] Extralobular sequestrations have distinct pleural covering and venous drainage, typically presents in the first 6 months of life, are less common, and often co-occur with other congenital abnormalities.[2] Intralobar pulmonary sequestrations are contiguous with normal lung, can present at any age, and can be acquired or congenital. In the former, the malformations may result from antecedent infection or bronchial obstruction with the isolated lung then developing accessory arterial supply from the aorta.[3] About one-third of bronchopulmonary sequestrations are identified in childhood and are typically asymptomatic – discovered incidentally through imaging. Adult diagnoses are almost always symptomatic and most commonly present in the 4th decade.[3] In these cases, infection is seeded into the sequestered lung tissue through interalveolar connections from adjacent normally aerated lung.[4] With no ability to clear infection through mucociliary escape, infection becomes trapped in the sequestered lung leading to cycles of infection and inflammation – commonly cough and hemoptysis.

There are currently no consensus treatment guidelines.[5] In adults, video-assisted thoracoscopic treatment is the most common approach,[6] though there has been in increase in treating sequestrations with minimally invasive embolization of the feeding artery.[7-9] In addition, pulmonary sequestrations have also been reported to regress spontaneously and, thus, may contribute to its low prevalence in adults.[10]

We describe the management of three adult patients with intralobar pulmonary sequestrations who were treated with transcatheter embolization.

CASE SERIES

Case 1

A 53-year-old female with a history of coronavirus pneumonia 7 months earlier presented to the emergency department with cough, shortness of breath, and back pain. She was tachycardic with a low-grade fever and mild leukocytosis. She reported pain with coughing that was ongoing for several years with recent exacerbation. She denied prior chest surgery or smoking history and was an active individual with a recent notable decrease in exercise tolerance. A chest computed tomography (CT) revealed an 8.3 × 7.0 × 9.6 cm heterogeneous rounded complex mass in the left lower lobe with multiple air-fluid levels and a vascular supply directly from the adjacent descending thoracic aorta [Figure 1]. These findings were consistent with sequestered pulmonary parenchyma with superimposed infection. The patient was discharged, referred to thoracic surgery and interventional radiology (IR), and was agreeable to pre-operative embolization; initially planned for debulking and hemostatic control for possible subsequent operative intervention.

A 53-year-old female with intralobar pulmonary sequestration who presented with cough, shortness of breath, and back pain. Initial contrast-enhanced coronal computed tomography chest demonstrates the extent of this mass craniocaudally (yellow arrows), as well as its relationship to the diaphragm, potentially complicating surgical intervention.
Figure 1:
A 53-year-old female with intralobar pulmonary sequestration who presented with cough, shortness of breath, and back pain. Initial contrast-enhanced coronal computed tomography chest demonstrates the extent of this mass craniocaudally (yellow arrows), as well as its relationship to the diaphragm, potentially complicating surgical intervention.

The procedure was performed under moderate sedation with radial artery access. Digital subtraction angiography of the aorta and selective angiography of first and second-order branches of the aorta supplying the pulmonary sequestration were obtained [Figure 2]. The anatomy was favorable for proximal embolization and a single Low-profile Braided Occluder (LOBO)-3 (Okami Medical, Aliso Viejo, CA) occlusion device was deployed in the first-order branch of the aorta supplying pulmonary sequestration [Figure 3]. Completion angiogram confirmed stasis and no further flow to the pulmonary sequestration was seen.

A 53-year-old female with intralobar pulmonary sequestration who presented with cough, shortness of breath, and back pain. Selective digital subtraction angiogram of the first-order aortic branch supplying the left lower lobe sequestration (yellow arrow).
Figure 2:
A 53-year-old female with intralobar pulmonary sequestration who presented with cough, shortness of breath, and back pain. Selective digital subtraction angiogram of the first-order aortic branch supplying the left lower lobe sequestration (yellow arrow).
A 53-year-old female with intralobar pulmonary sequestration who presented with cough, shortness of breath, and back pain. Post-embolization digital subtraction angiogram shows successful embolization (yellow arrow).
Figure 3:
A 53-year-old female with intralobar pulmonary sequestration who presented with cough, shortness of breath, and back pain. Post-embolization digital subtraction angiogram shows successful embolization (yellow arrow).

One month follow-up chest CT showed approximately 50% volume reduction of the sequestered lung with decreased surrounding inflammatory changes. Subsequent follow-ups continued to show improvement and at 9 months post-procedure, the region of pulmonary sequestration measured 1.5 × 2.2 × 3.1 cm [Figure 4]. The patient reported complete resolution of her shortness of breath, pain, and coughing. She continued to do well and did not require surgical intervention.

A 53-year-old female with intralobar pulmonary sequestration who presented with cough, shortness of breath, and back pain. Nine-month follow-up coronal computed tomography chest without contrast demonstrates the significant decrease in the extent of the sequestration (yellow arrow), as well as decreased interaction with the underlying diaphragm.
Figure 4:
A 53-year-old female with intralobar pulmonary sequestration who presented with cough, shortness of breath, and back pain. Nine-month follow-up coronal computed tomography chest without contrast demonstrates the significant decrease in the extent of the sequestration (yellow arrow), as well as decreased interaction with the underlying diaphragm.

Case 2

A 70-year-old female with hypertension, hyperlipidemia, hypothyroidism, and 15-year history of a chronic, dry cough presented with progressive coughing episodes that resulted in bouts of hemoptysis. The patient had previously been treated for bronchitis, asthma, and reflux disease in the past. At least, two non-contrast chest CT examinations had been performed demonstrating bibasilar consolidation. The patient developed worsening hemoptysis and a contrast-enhanced CT of the chest was performed in planned evaluation of the bronchial arteries. The examination resulted in an unanticipated finding of systemic arterial supply to the basilar consolidations [Figure 5]. This allowed for a diagnosis of bilateral intralobar sequestration. After a multispecialty discussion, it was determined that an arterial embolization using an endovascular approach was the safest initial treatment.

A 70-year-old female with bilateral intralobar pulmonary sequestration who presented with progressive cough with hemoptysis. Initial axial computed tomography angiogram of the chest demonstrates the intralobar pulmonary sequestration (yellow arrows).
Figure 5:
A 70-year-old female with bilateral intralobar pulmonary sequestration who presented with progressive cough with hemoptysis. Initial axial computed tomography angiogram of the chest demonstrates the intralobar pulmonary sequestration (yellow arrows).

The procedure was performed with moderate sedation using common femoral artery access. The common arterial trunk arose from the left gastric artery and the bifurcating left and right segmental branches [Figure 6] were embolized using 4 mm Concerto detachable coils (Medtronic, Fridley, MN). The coil pack was then extended proximally to embolize the common trunk with 6 mm coils [Figure 7]. The angiographic endpoint was flow stasis. The patient was discharged on the same day of the procedure after a 2-h recovery.

A 70-year-old female with bilateral intralobar pulmonary sequestration who presented with progressive cough with hemoptysis. Digital subtraction angiogram from the left gastric artery demonstrates the segmented arterial supply (yellow arrow).
Figure 6:
A 70-year-old female with bilateral intralobar pulmonary sequestration who presented with progressive cough with hemoptysis. Digital subtraction angiogram from the left gastric artery demonstrates the segmented arterial supply (yellow arrow).
A 70-year-old female with bilateral intralobar pulmonary sequestration who presented with progressive cough with hemoptysis. Post-embolization digital subtraction angiogram from the celiac axis demonstrates cessation of flow to the sequestration (yellow arrow).
Figure 7:
A 70-year-old female with bilateral intralobar pulmonary sequestration who presented with progressive cough with hemoptysis. Post-embolization digital subtraction angiogram from the celiac axis demonstrates cessation of flow to the sequestration (yellow arrow).

At 4 months, a CT angiogram was performed demonstrating no parenchymal enhancement of the sequestration. At 5 months, the patient reports being asymptomatic with resolved cough, no new episodes of hemoptysis, and improved breathing.

Case 3

A 70-year-old male with known left lower lobe pulmonary sequestration presented with sub-massive hemoptysis. On presentation, he was hemodynamically stable, with a hematocrit of 39%, previously 43% 2 months ago. He had mild subjective dyspnea, but oxygen saturation of 97% on room air. Initial CT revealed an aberrant branch from the aorta supplying the sequestration, without any other contributing supply [Figure 8]. Thoracic surgery was consulted for resection and IR was consulted for embolization. A multi-disciplinary approach of urgent embolization followed by medical optimization and subsequent resection in the short term was agreed on.

A 70-year-old male with intralobar pulmonary sequestration who presented with sub-massive hemoptysis. Contrast-enhanced sagittal computed tomography chest demonstrates a large caliber vessel with 2 dominant branches supplying the sequestration (yellow arrow).
Figure 8:
A 70-year-old male with intralobar pulmonary sequestration who presented with sub-massive hemoptysis. Contrast-enhanced sagittal computed tomography chest demonstrates a large caliber vessel with 2 dominant branches supplying the sequestration (yellow arrow).

Arterial access was obtained through the right common femoral artery. An aortagram was performed which demonstrated a large aberrant artery arising from the aorta at the level of the celiac axis. First-order branches of this vessel were selected [Figure 9] and coil embolization was performed with multiple detachable Ruby Coils (Penumbra Inc., Alameda, California) up to the confluence, to allow enough room for cross-clamp and resection during eventual surgical resection [Figure 10]. Post-embolization angiogram through both the microcatheter and the parent catheter demonstrates occlusion of the culprit vessel.

A 70-year-old male with intralobar pulmonary sequestration who presented with sub-massive hemoptysis. Digital subtraction angiogram demonstrates arterial inflow supplying the pulmonary sequestration (yellow arrow).
Figure 9:
A 70-year-old male with intralobar pulmonary sequestration who presented with sub-massive hemoptysis. Digital subtraction angiogram demonstrates arterial inflow supplying the pulmonary sequestration (yellow arrow).
A 70-year-old male with intralobar pulmonary sequestration who presented with sub-massive hemoptysis. Post-embolization digital subtraction angiogram shows successful embolization (yellow arrow) with sparing of the vessel trunk to facilitate cross-clamping during future resection.
Figure 10:
A 70-year-old male with intralobar pulmonary sequestration who presented with sub-massive hemoptysis. Post-embolization digital subtraction angiogram shows successful embolization (yellow arrow) with sparing of the vessel trunk to facilitate cross-clamping during future resection.

The patient’s hemoptysis resolved overnight, with stabilization of hematocrit. He was discharged 4 days after presentation. Definitive surgical resection was performed 9 weeks later by thoracic surgery.

DISCUSSION

Pulmonary sequestration is a rare congenital lung malformation. Although it can be an incidental finding in asymptomatic patients, it is also associated with serious complications such as massive hemoptysis, recurrent respiratory infections, and heart failure. As a result, the treatment for symptomatic patients has historically been surgical resection.[11] A possible cause for low adult prevalence of pulmonary sequestration is due to the evidence of spontaneous regression.[12] This is thought to be the result of progressive fibrosis of the dysplastic lung tissue and feeding blood vessel which eventually results in thrombosis and infarction.[13] A transcatheter embolization technique takes advantage of this mechanism by occluding the arterial supply, leading to infarction of the sequestration. Although there is currently limited literature describing endovascular management for pulmonary sequestration, this creates room for conversation regarding the optimal management for these patients.

As the above cases demonstrated, endovascular treatment can be performed through femoral or radial arterial access. Depending on the patient’s anatomy, a variety of catheters can be used to allow for selective and superselective angiography. Once at the vessel of interest, the operator’s choice of embolic can be deployed to achieve total occlusion. Here, we have demonstrated use of plugs and endovascular coils, though there is evidence of case reports which have utilized embolic agents such as polyvinyl alcohol (PVA) particles, gelfoam, and glue in addition to coils and plugs.[7-9] Final angiography is necessary to confirm total occlusion and follow-up imaging can be obtained to track the size of the pulmonary sequestration over time.

Embolization has been reported to be effective in pediatric cases with a low complication rate; however, repeat embolization may be required for some patients. Long-term follow-up for pulmonary sequestration post-embolization is limited; however, the imaging findings presented here suggest that it may be an effective and definitive treatment in patients with amenable anatomy and targetable arterial supply. Potential limitations of transcatheter embolization include contrast usage, relative contraindication in patients with kidney failure, and radiation exposure, though this is thought to be less of a concern in adult patients. Advantages of this approach include its minimally invasive nature which does not necessitate hospitalization or general anesthesia, and rapid recovery time. Potential complications include non-target embolization, for which, meticulous angiographic techniques should be deployed. Although there are currently no randomized control trials to compare patient outcomes after embolization versus surgical resection, these cases further supports existing case series that suggest the efficacy of this minimally invasive approach for patients with this disease process. Further, investigation directly comparing this angiographic approach to surgery may be limited due to the prevalence of the disease process. Given multiple potential embolization strategies, these cases suggest that definitive proximal embolization of the feeding vessels may be an effective treatment strategy that warrants further investigation.

CONCLUSION

Proximal arterial embolization of pulmonary sequestration may be a safe, effective, and durable minimally invasive treatment for adults with symptomatic pulmonary sequestration, and possibly negate the need for surgery. Further, investigation may help clarify the best mode of embolization as well as compare outcomes with surgical resection.

Ethical approval

The Institutional Review Board approval is not required.

Declaration of patient consent

Patient’s consent is not required as patients identity is not disclosed or compromised.

Conflicts of interest

There are no conflicts of interest.

Use of artificial intelligence (AI)-assisted technology for manuscript preparation

The authors confirm that there was no use of artificial intelligence (AI)-assisted technology for assisting in the writing or editing of the manuscript and no images were manipulated using AI.

Financial support and sponsorship

Nil.

References

  1. , , , , . Lung sequestration: Report of seven cases and review of 540 published cases. Thorax. 1979;34:96-101.
    [CrossRef] [Google Scholar]
  2. , . Pulmonary sequestration. Paediatr Respir Rev. 2004;5:59-68.
    [CrossRef] [Google Scholar]
  3. , , , . Intralobar sequestration: Radiologic-pathologic correlation. Radiographics. 1997;17:725-45.
    [CrossRef] [Google Scholar]
  4. , . The clinical significance of collateral ventilation. Ann Am Thorac Soc. 2016;13:2251-7.
    [CrossRef] [Google Scholar]
  5. , , , , , , et al. Treatment strategies for pulmonary sequestration in childhood: Resection, embolization, observation? Acta Cardiol. 2012;67:629-34.
    [CrossRef] [Google Scholar]
  6. , . Pulmonary sequestration in adults: A retrospective review of resected and unresected cases. BMC Pulm Med. 2018;18:97.
    [CrossRef] [Google Scholar]
  7. , , . Transcatheter embolization for massive hemoptysis from an intralobar pulmonary sequestration: A case report. Clin Imaging. 2014;38:326-9.
    [CrossRef] [Google Scholar]
  8. , , , , , , et al. Successful endovascular embolization of an intralobar pulmonary sequestration. Radiol Case Rep. 2018;13:125-9.
    [CrossRef] [Google Scholar]
  9. , , , , , , et al. Transarterial embolization of intralobar pulmonary sequestration in a young adult with hemoptysis. J Thorac Dis. 2017;9:E188-93.
    [CrossRef] [Google Scholar]
  10. , . Pulmonary sequestration: A retrospective analysis of 2625 cases in China. Eur J Cardiothorac Surg. 2011;40:e39-42.
    [CrossRef] [Google Scholar]
  11. , , , , . Intralobar pulmonary sequestration in 2 extremes of ages: A Case report. Radiol Case Rep. 2023;18:4145-8.
    [CrossRef] [Google Scholar]
  12. , , , , . Spontaneous involution of pulmonary sequestration in children: A report of two cases and review of the literature. Pediatr Radiol. 1998;28:266-70.
    [CrossRef] [Google Scholar]
  13. , , , , , , et al. Transcatheter arterial embolization of pulmonary sequestration in neonates: Long-term follow-up results. J Vasc Interv Radiol. 2003;14:363-7.
    [CrossRef] [Google Scholar]
Show Sections