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Original research article


Unintended thermal injuries from radiofrequency ablation: organ protection with an angioplasty balloon catheter in an animal model.

Martha-Grace KnuttinenThuong G Van HaChristopher ReillyAnthony MontagChristopher Straus
Department of Vascular and Interventional Radiology, University of Illinois Hospital and Health Sciences System, Chicago, Illinois 60612Departments of Interventional Radiology, and Pathology, University of Chicago Medical Center, Chicago, Illinois 60637, USA
Date of Submission: 22-Aug-2013, Date of Acceptance: 04-Oct-2013, Date of Web Publication: 30-Jan-2014.
Corresponding Author:
Corresponding Author

Martha‑Grace Knuttinen

Department of Vascular and Interventional Radiology, University of Illinois Hospital and Health Sciences System, MC 931, 1741 W. Taylor Street, Chicago, Illinois 60612, USA.
E-mail: mgk600@hotmail.com

Corresponding Author:
Corresponding Author

Martha‑Grace Knuttinen

Department of Vascular and Interventional Radiology, University of Illinois Hospital and Health Sciences System, MC 931, 1741 W. Taylor Street, Chicago, Illinois 60612, USA.
E-mail: mgk600@hotmail.com

DOI: 10.4103/2156-7514.126018 Facebook Twitter Google Linkedin

ABSTRACT


Objectives: The aim of this study was to investigate a novel approach of using a balloon catheter as a protective device to separate liver from the diaphragm or nearby bowel during radiofrequency ablation (RFA) of hepatic dome tumors in an animal model. Materials and Methods: All experimental procedures were approved by animal Institutional Review Board. Using a 3 cm RF needle electrode, 70 hepatic ablation zones were created using ultrasound in 7 pigs. 50 lesions were created using balloon interposition between liver and diaphragm; 20 lesions were created using the balloon device interposed posteriorly between liver and bowel. Additional 21 control lesions were performed. Animals were sacrificed immediately; diaphragm and bowel were then visually inspected and sectioned. Diaphragmatic and bowel injury was then classified according to the depth of thickness. Results: Control lesions caused full thickness injury, either to diaphragm or bowel. During ablation of lesions with balloon interposition, there was significantly less diaphragmatic injury, P < 0.001 and less bowel injury, P < 0.01. Conclusion: Using balloon interposition as a protective device has advantages over previous saline infusion or CO2 insufflation, providing a safe way to expand percutaneous RFA of liver tumors located on the undersurface of the diaphragm. In addition, this method may be used in protection of other organs adjacent to areas being ablated.
Keywords: Ablation, Diaphragm, Liver Tumor, Organ Protection

Cited in 5 Documents

  1. Sharath K. Bhagavatula, Jeffrey F. B. Chick, Nikunj R. Chauhan and Paul B. Shyn (2017) Artificial ascites and pneumoperitoneum to facilitate thermal ablation of liver tumors: a pictorial essay. Abdom Radiol 42(2):620. doi: 10.1007/s00261-016-0910-9
  2. Yi-Chung Hsieh, Jenny L. Limquiaco, Chen-Chun Lin, Wei-Ting Chen and Shi-Ming Lin (2019) Radiofrequency ablation following artificial ascites and pleural effusion creation may improve outcomes for hepatocellular carcinoma in high-risk locations. Abdom Radiol 44(3):1141. doi: 10.1007/s00261-018-1831-6
  3. M. Medhioub, M. L. Hamzaoui, H. Dabbebi, M. H. Ezzine, E. Chelbi, K. Bouzaidi and M. M. Azzouz (2015) Mélanome anorectal primaire prolabé par l’anus : piège diagnostique. Acta Endosc 45(1-2):12. doi: 10.1007/s10190-015-0431-3
  4. Susan C. Harvey, Ashok Vegesna, Sharon Mass, Janice Clarke and Alexandria Skoufalos (2014) Understanding Patient Options, Utilization Patterns, and Burdens Associated with Breast Cancer Screening. Journal of Women's Health 23(S1):S-3. doi: 10.1089/jwh.2014.1510
  5. Avinash Kambadakone, Vinit Baliyan, Hamed Kordbacheh, Raul N Uppot, Ashraf Thabet, Debra A Gervais and Ronald S Arellano (2017) Imaging guided percutaneous interventions in hepatic dome lesions: Tips and tricks. WJH 9(19):840. doi: 10.4254/wjh.v9.i19.840

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