Schizencephaly is a brain-destructive lesion relating to clefts in the fetal brain that usually communicate with the ventricular system, subarachnoid space, or both. It presents as two types: Type I (closed) and Type II (open). During pregnancy, it may be suspected in the course of ultrasonography, which highlights ventricular dilatation and brain abnormalities. Usually, the diagnosis is confirmed postnatally using trans-fontanel ultrasonography. The etiology of schizencephaly is still unknown, but it may be derived from a primary disorder of brain development or from bilateral middle cerebral artery occlusion. Many causative agents including vascular insult, infections, toxins, and medications have been associated with this malformation. We present a pictorial essay of six cases of schizencephaly that were suspected on prenatal ultrasound scans and confirmed postnatally by trans-fontanel, two-dimensional and three-dimensional ultrasonography.
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Gunes Orman, Jane E. Benson, Charlotte F. Kweldam, Thangamadhan Bosemani, Aylin Tekes, M. Robert de Jong, Donna Seyfert, Frances J. Northington, Andrea Poretti and Thierry A. G. M. Huisman (2015) Neonatal Head Ultrasonography Today: A Powerful Imaging Tool!. J Neuroimaging25(1):31. doi: 10.1111/jon.12108
Mehmet Serdar Kutuk, Sureyya Burcu Gorkem, Ayse Bayram, Selim Doganay, Mehmet Canpolat and Mustafa Basbug (2015) Prenatal Diagnosis and Postnatal Outcome of Schizencephaly. J Child Neurol30(10):1388. doi: 10.1177/0883073814556312
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